John Domagala

CAREER SUMMARY

Over 30 years of infectious disease experience in Warner-Lambert/Pfizer with broad based training in medicinal chemistry, management, building program portfolios, and attrition analysis. Managerial experience included 8 years supervision of research teams (4-14 colleagues) and 7 years of TA leadership (30- over 100 colleagues at two sites) with full responsibilities for TA chemistry and biology strategy, product profiles, patents, publications, product development, and in licensing. Brought 30 compounds into full development with 8 compounds reaching the clinic. Medicinal chemistry experience included bringing leads from HTS to full development. Product development experience included in depth understanding of market needs and trends, as well as all aspects of preclinical safety and PK assessments.

KEY ACCOMPLISHMENTS

Drug Discovery

  • Discovered multiple clinical candidates within Antibacterials and Antivirals
    • Quinolones
    • Beta-lactams
    • Oxazolidinones
    • Topoisomerase inhibitors
    • HIV-protease inhibitors
    • HIV-NP7 inhibitors
  • Published the first in depth structure activity and safety study in the quinolone field which was cited over 300 times
  • Developed and prosecuted antibacterial portfolio including over 25 projects at two sites
  • Evaluated over 100 in license opportunities with 5 being successfully integrated into Pfizer's portfolio
  • Led the chemical development/optimization of multiple products from HTS to clinic
  • Key contributions in identifying and solving crucial safety and PDM issues arising in product development

Management/Leadership

  • Managed several multi-disciplined (chemistry, biology, safety, PDM, marketing, regulatory etc) project teams
  • Managed the Antiinfective chemistry group for 8 years at Warner-Lambert (30 colleagues)
  • Managed the Pfizer Antibacterial TA for 7 years (over 100 colleagues) at two sites.
  • Led multiple task forces including attrition analysis team
  • Managed the antibacterial licensing team and led three in depth analysis teams

Innovation and leadership in discovery by Publications and Patents

  • Over 100 publications/presentations
  • Over 15 invited presentations
  • Over 30 patents

Business Development

  • Led and developed a discovery wide resource allocation/ portfolio model which governed the overall productivity of the site
  • Analyzed industry wide attrition trends and made sweeping discovery recommendations to minimize future attrition which were embraced by Pfizer
  • Led multiple acquisition integration teams which integrated all the science and personnel of acquired companies.

EDUCATION

Ph.D. Organic Chemistry 1977
Wayne State University

BS Chemistry 1973
University of Detroit

MEMBERSHIPS / AFFILIATIONS

American Chemical Society
American Society of Microbiology
30 years of private and public tutoring in Math, chemistry and Pharmacology